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Sperm generally have no surface antigens

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    Spermatozoa interact with their immediate environment and this contact remodels the sperm surface in preparation for fertilisation. These fundamental membrane changes will be critically covered in this review with special emphasis on the very specific surface destabilisation event, capacitation. This process involves very subtle and intricate modifications of the sperm membrane including removal of suppression decapacitation factors and changes in the lateral organisation of the proteins and lipids of the sperm surface. Processing of sperm for assisted reproduction storage, sex-sorting, etc. To improve sperm quality, novel mechanisms must be used to stabilise the sperm surface during handling.
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    Sperm surface changes and physiological consequences induced by sperm handling and storage

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    Identification of sperm immunoreactive antigens for immunocontraceptive purposes: a review

    Ian A. Brewis, Barend M. Proteomics technologies have matured significantly in recent years and proteomics driven research articles in reproductive biology and medicine are increasingly common. The key challenge is to move from lists of identified proteins to informed understanding of biological function. This review introduces the range of proteomics workflows most commonly used for protein identification before focusing on the mammalian sperm cell at fertilization as an exemplar for proteomic studies. We review the work of others on entire cells but then argue that proper subcellular fractionation and proper solubilization strategies offers critical advantages to achieving increased biological understanding.
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    Sperm specific proteins-potential candidate molecules for fertility control

    Try out PMC Labs and tell us what you think. Learn More. Antisperm antibodies ASA may be a reason of infertility in some individuals. They may affect pre- as well as post-fertilization stages of the reproductive process.
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    Reproductive Biology and Endocrinology volume 2 , Article number: 10 Cite this article. Metrics details. The increase in population growth rate warrants the development of additional contraceptive methods that are widely acceptable, free from side effects and less expensive. Immunocontraception, and in particular the targeting of antibodies to gamete-specific antigens implicated in sperm egg binding and fertilization, offers an attractive approach to control fertility. The development of a contraceptive vaccine based on sperm antigen represents a promising approach to contraception.
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